While there are few controlled data on the optimal use of benzodiazepines in conjunction with SSRIs for panic, this treatment strategy shows promise as a reliable and safe approach for the stabilization of acute panic disorder.Īccordingly, the purpose of our study was to determine, in a controlled manner, whether early coadministration of the benzodiazepine, clonazepam, with the SSRI, sertraline, would facilitate rapid clinical stabilization of panic symptoms relative to the administration of sertraline alone. However, more firm conclusions await completion of this trial. Pollack, MD, Harvard University, Cambridge, Mass, 2001). Interim results of a controlled study by another group, examining the additive effects of either brief or sustained combined treatment with clonazepam in patients with panic disorder receiving paroxetine, suggested that the benefits of combined treatment are primarily immediate (e-mail communication, Mark H. Other researchers, using a naturalistic study design, have begun to report evidence of early antipanic efficacy of a paroxetine/clonazepam coadministration strategy, 3 with uneventful tapering of this benzodiazepine regimen. 2 However, in this trial, the alprazolam dosage proved difficult to taper, which in turn had a negative ongoing effect on clinical state in the combination treatment group.
![clonazepam half life clonazepam half life](https://minio.scielo.br/documentstore/1678-4227/9GrBwzmfHSXPt7SM3trqNfd/1fad52b15322648ae8290e9629478abb2fd812c1.gif)
A previous study by our group documented the early antipanic efficacy of an imipramine/alprazolam regimen for the stabilization treatment of panic disorder.
#CLONAZEPAM HALF LIFE HOW TO#
1 However, there are few controlled studies to guide the physician on how to best accomplish this. This difference was not observed at other times during the trial.Ĭonclusion These data indicate that rapid stabilization of panic symptoms can be safely achieved with a sertraline/clonazepam combination, supporting the clinical utility of this type of regimen for facilitating early improvement of panic symptoms relative to sertraline alone.ĬOMBINING benzodiazepines with selective serotonin reuptake inhibitors (SSRIs) and other antidepressant-like agents during the course of treatment for panic disorder seems to be a common clinical practice. There was also a significant between-group difference at the end of week 3 with 14 (63%) of 22 of the sertraline/clonazepam group responding to treatment vs 8 (32%) of 25 of the sertraline/placebo group ( P =.
#CLONAZEPAM HALF LIFE TRIAL#
An intent-to-treat analysis (on last observation carried forward data) revealed a much greater proportion of responders in the sertraline/clonazepam compared with the sertraline/placebo group at the end of week 1 of the trial (41% vs 4%) ( P =. Drop-out rates were similar in the sertraline/placebo vs the sertraline/clonazepam group (38% vs 25%) ( P =. Results Thirty-four (68%) of 50 patients completed the trial. The clonazepam dose was then tapered during 3 weeks and discontinued. Patients received open-label sertraline for 12 weeks (target dose, 100 mg/d), and in addition were randomized to groups receiving either 0.5 mg of active clonazepam 3 times daily or placebo clonazepam for the first 4 weeks of the trial. Methods Fifty patients with panic disorder were randomized into a double-blind clinical trial. The purpose of this study was to test the efficacy of early coadministration of clonazepam with sertraline in the treatment of panic disorder. Although this medication combination is widely used in clinical practice, there is no well-tested, optimal method of coadministering these medications for the treatment of panic disorder.
![clonazepam half life clonazepam half life](https://slideplayer.com/slide/13067549/79/images/4/CLONAZEPAM+Starting+Dose+How+to+Titrate+Maximum+Dose+Onset+Half-life.jpg)